Specificity and selectivity in post-translational biotin addition
نویسندگان
چکیده
منابع مشابه
Gene selection, alternative splicing, and post-translational processing regulate neuroligin selectivity for beta-neurexins.
Neuroligins 1-4 are postsynaptic transmembrane proteins capable of initiating presynaptic maturation via interactions with beta-neurexin. Both neuroligins and beta-neurexins have alternatively spliced inserts in their extracellular domains. Using analytical ultracentrifugation, we determined that the extracellular domains of the neuroligins sediment as dimers, whereas the extracellular domains ...
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Introduction Covalently attached prosthetic groups serve as swinging arms in several different and wellcharacterized multifunctional enzymes. Notable among these are the lipoyl-lysine residues in 2-0x0 acid dehydrogenase multienzyme complexes [l-31 and the glycine cleavage system [4-61, the biotinyl-lysine residues in various ATP-dependent carboxylases [7,8] and the phosphopantetheinyl-serine r...
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The specificity of protein synthesis in reovirus-infected mouse SC-1 cells was investigated, with the following results: a, extracts from infected and control cells translated saturating levels of capped globin mRNA with the same efficiency; b, infected cell extracts did not display a virus-induced increase in the capacity to translate decapped globin mRNA; c, translation of both cellular and v...
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Malaria is one of the most important human parasitic diseases in the world, affecting about 400 million people and killing about 1 million children every year. Our relationship with the malarial parasite has been a long one on the evolutionary scale, and the methods adopted by the parasite to thrive and colonize our bodies are truly fascinating. In order to control the disease, it is of fundame...
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ژورنال
عنوان ژورنال: Biochemical Society Transactions
سال: 2018
ISSN: 0300-5127,1470-8752
DOI: 10.1042/bst20180425